Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumors.

Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumors.

Recently, investigators showed that mice with syngeneic murine gliomas that were treated with a neuroattenuated oncolytic herpes simplex virus-1 (oHSV), M002, had a significant increase in survival. M002 has deletions in both copies of the γ134.5 gene, enabling replication in tumor cells but preclud...

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Bibliographic Details
Main Authors: Michael L Megison, Lauren A Gillory, Jerry E Stewart, Hugh C Nabers, Elizabeth Mroczek-Musulman, Alicia M Waters, Jennifer M Coleman, Virginia Kelly, James M Markert, G Yancey Gillespie, Gregory K Friedman, Elizabeth A Beierle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3907427?pdf=render

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http://europepmc.org/articles/PMC3907427?pdf=render

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