HADC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-Induced Mouse Model of Neuroinflammation and Microglial Activation

Glial activation and neuroinflammatory processes play important roles in the pathogenesis of brain abscess and neurodegenerative diseases. Activated glial cells can secrete various proinflammatory cytokines and neurotoxic mediators, which contribute to the exacerbation of neuronal cell death. The in...

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Bibliographic Details
Main Authors: Fan-Li Lin, Jing-Lun Yen, Yu-Cheng Kuo, Jaw-Jou Kang, Yu-Wen Cheng, Wei-Jan Huang, George Hsiao
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
Akt
Online Access:http://www.mdpi.com/1422-0067/20/2/410