Nontrivial Replication of Loci Detected by Multi-Trait Methods

Nontrivial Replication of Loci Detected by Multi-Trait Methods

The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power. Howev...

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Bibliographic Details
Main Authors: Zheng Ning, Yakov A. Tsepilov, Sodbo Zh. Sharapov, Zhipeng Wang, Alexander K. Grishenko, Xiao Feng, Masoud Shirali, Peter K. Joshi, James F. Wilson, Yudi Pawitan, Chris S. Haley, Yurii S. Aulchenko, Xia Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Genetics
Subjects:
pleiotropy
multivariate analysis
genome-wide association study
cross-phenotype association
replication
genotype-phenotype map
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.627989/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.627989/full

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