A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

Cholinergic dysfunction is strongly implicated in dystonia pathophysiology. Previously (Pappas et al., 2015;4:e08352), we reported that Dlx5/6-Cre mediated forebrain deletion of the DYT1 dystonia protein torsinA (Dlx-CKO) causes abnormal twisting and selective degeneration of dorsal striatal choline...

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Bibliographic Details
Main Authors: Samuel S Pappas, Jay Li, Tessa M LeWitt, Jeong-Ki Kim, Umrao R Monani, William T Dauer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
dystonia
cholinergic
neurodegeneration
DYT1
torsinA
motor behavior
Online Access:https://elifesciences.org/articles/36691

Internet

https://elifesciences.org/articles/36691

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