IgM Antibody Repertoire Fingerprints in Mice Are Personalized but Robust to Viral Infection Status

IgM Antibody Repertoire Fingerprints in Mice Are Personalized but Robust to Viral Infection Status

Antibody repertoire sequencing provides a molecular fingerprint of current and past pathogens encountered by the immune system. Most repertoire studies in humans require measuring the B cell response in the blood, resulting in a large bias to the IgM isotype. The extent to which the circulating IgM...

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Bibliographic Details
Main Authors: Alexander Yermanos, Nike Julia Kräutler, Alessandro Pedrioli, Ulrike Menzel, Victor Greiff, Tanja Stadler, Annette Oxenius, Sai T. Reddy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
adaptive immune receptor repertoire sequencing
B cell
deep sequencing
antibody repertoire
viral infection
LCMV (lymphocytic choriomeningitis virus)
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00254/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00254/full

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