CK1/Doubletime activity delays transcription activation in the circadian clock

CK1/Doubletime activity delays transcription activation in the circadian clock

In the Drosophila circadian clock, Period (PER) and Timeless (TIM) proteins inhibit Clock-mediated transcription of per and tim genes until PER is degraded by Doubletime/CK1 (DBT)-mediated phosphorylation, establishing a negative feedback loop. Multiple regulatory delays within this feedback loop en...

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Bibliographic Details
Main Authors: Deniz Top, Jenna L O'Neil, Gregory E Merz, Kritika Dusad, Brian R Crane, Michael W Young
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-04-01
Series:eLife
Subjects:
circadian rhythms
Doubletime
phosphorylation
transcription regulation
protein degradation
Online Access:https://elifesciences.org/articles/32679

Internet

https://elifesciences.org/articles/32679

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