Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects

Deleterious genetic variants in ciliopathy genes increase risk of ritodrine-induced cardiac and pulmonary side effects

Abstract Background Ritodrine is a commonly used tocolytic to prevent preterm labour. However, it can cause unexpected serious adverse reactions, such as pulmonary oedema, pulmonary congestion, and tachycardia. It is unknown whether such adverse reactions are associated with pharmacogenomic variants...

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Bibliographic Details
Main Authors: Heewon Seo, Eun Jin Kwon, Young-Ah You, Yoomi Park, Byung Joo Min, Kyunghun Yoo, Han-Sung Hwang, Ju Han Kim, Young Ju Kim
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Medical Genomics
Subjects:
Ritodrine
Pulmonary oedema
Whole-exome sequencing
Ciliopathy
Joubert syndrome
Online Access:http://link.springer.com/article/10.1186/s12920-018-0323-4

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http://link.springer.com/article/10.1186/s12920-018-0323-4

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