Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog.

Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog.

Cardiac ischemia and reperfusion (I/R) injury occurs because the acute increase in oxidative/inflammatory stress during reperfusion culminates in the death of cardiomyocytes. Currently, there is no drug utilized clinically that attenuates I/R injury in patients. Previous studies have demonstrated de...

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Bibliographic Details
Main Authors: Junying Zheng, Chih-Chang Wei, Naoki Hase, Ke Shi, Cheryl R Killingsworth, Silvio H Litovsky, Pamela C Powell, Tsunefumi Kobayashi, Carlos M Ferrario, Andras Rab, Inmaculada Aban, James F Collawn, Louis J Dell'Italia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3986229?pdf=render

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http://europepmc.org/articles/PMC3986229?pdf=render

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