Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

Abstract Background Emerging evidence indicates that impaired mitophagy-mediated clearance of defective mitochondria is a critical event in Alzheimer’s disease (AD) pathogenesis. Amyloid-beta (Aβ) metabolism and the microtubule-associated protein tau have been reported to regulate key components of...

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Bibliographic Details
Main Authors: Vicente Roca-Agujetas, Elisabet Barbero-Camps, Cristina de Dios, Petar Podlesniy, Xenia Abadin, Albert Morales, Montserrat Marí, Ramon Trullàs, Anna Colell
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Neurodegeneration
Subjects:
APP-PSEN1 mice
Mitochondria
Glutathione
Oxidative stress
PINK1
Parkin
Online Access:https://doi.org/10.1186/s13024-021-00435-6

Internet

https://doi.org/10.1186/s13024-021-00435-6

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