Stir bar-sorptive extraction, solid phase extraction and liquid-liquid extraction for levetiracetam determination in human plasma: comparing recovery rates

Stir bar-sorptive extraction, solid phase extraction and liquid-liquid extraction for levetiracetam determination in human plasma: comparing recovery rates

<p>Levetiracetam (LEV), an antiepileptic drug (AED) with favorable pharmacokinetic profile, is increasingly being used in clinical practice, although information on its metabolism and disposition are still being generated. Therefore a simple, robust and fast liquid-liquid extraction (LLE) foll...

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Bibliographic Details
Main Authors: Priscila Freitas-Lima, Flavia Isaura Santi Ferreira, Carlo Bertucci, Veriano Alexandre Júnior, Sônia Aparecida Carvalho Dreossi, Leonardo Regis Leira Pereira, Américo Ceiki Sakamoto, Regina Helena Costa Queiroz
Format: Article
Language:English
Published: Universidade de São Paulo 2015-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Levetiracetam/farmacocinética
Cromatografia líquida de alta eficiência
Antiepiléticos/ monitorização terapêutica
Epilepsia/tratamento
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200393&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200393&lng=en&tlng=en

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