Nasal Absorption of Macromolecules from Powder Formulations and Effects of Sodium Carboxymethyl Cellulose on Their Absorption.

The nasal absorption of macromolecules from powder formulations and the effect of sodium carboxymethyl cellulose (CMC-Na) as a pharmaceutical excipient on their absorption were studied. Model macromolecules were fluorescein isothiocyanate-labeled dextran (average molecular weight of 4.4kDa, FD4) and...

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Bibliographic Details
Main Authors: Akiko Tanaka, Tomoyuki Furubayashi, Akifumi Matsushita, Daisuke Inoue, Shunsuke Kimura, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5012702?pdf=render