siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection.

siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection.

Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based siRNA screen. We revealed an actin-remodeling pa...

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Bibliographic Details
Main Authors: Sheli R Radoshitzky, Gianluca Pegoraro, Xi Olì Chī, Lián D Ng, Chih-Yuan Chiang, Lucas Jozwick, Jeremiah C Clester, Christopher L Cooper, Duane Courier, David P Langan, Knashka Underwood, Kathleen A Kuehl, Mei G Sun, Yíngyún Caì, Shu Qìng Yú, Robin Burk, Rouzbeh Zamani, Krishna Kota, Jens H Kuhn, Sina Bavari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4816540?pdf=render

Internet

http://europepmc.org/articles/PMC4816540?pdf=render

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