Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential

Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential

Abstract Background The differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) has great power as a novel treatment for ocular surface reconstruction and for modeling corneal epithelial renewal. However, the lack of profound understanding of the true LSC popula...

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Bibliographic Details
Main Authors: Meri Vattulainen, Tanja Ilmarinen, Laura Koivusalo, Keijo Viiri, Heidi Hongisto, Heli Skottman
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Human pluripotent stem cells
Stem cell differentiation
Limbal stem cells
Stem cell hierarchy
Stem cell maintenance
Wnt signaling
Online Access:http://link.springer.com/article/10.1186/s13287-019-1354-2

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http://link.springer.com/article/10.1186/s13287-019-1354-2

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