Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method

Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method

This study aimed to investigate the role of micellization of sodium lauryl sulfate (SLS) in poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using the anti-solvent method in enhancing the dissolution rate of practically water-insoluble cilostazol (CLT). Herein, SLS was incorporated into C...

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Bibliographic Details
Main Authors: Gang Jin, Hai V. Ngo, Jing-Hao Cui, Jie Wang, Chulhun Park, Beom-Jin Lee
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
water-insoluble cilostazol
solid dispersion
anti-solvent method
micellization of sodium lauryl sulfate
enhanced dissolution
partial amorphous state
Online Access:https://www.mdpi.com/1999-4923/13/5/662

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https://www.mdpi.com/1999-4923/13/5/662

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