The ETS Inhibitor YK-4-279 Suppresses Thyroid Cancer Progression Independent of TERT Promoter Mutations

The ETS Inhibitor YK-4-279 Suppresses Thyroid Cancer Progression Independent of TERT Promoter Mutations

Hotspot mutations in the core promoter region of the telomerase reverse transcriptase (TERT) gene have been well established to associate with aggressive clinical characteristics, radioiodine refractory, tumor recurrence, and mortality in thyroid cancer. Several E-twenty-six (ETS) transcription fact...

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Bibliographic Details
Main Authors: Junyu Xue, Shiyong Li, Peijie Shi, Mengke Chen, Shuang Yu, Shubin Hong, Yanbing Li, Rengyun Liu, Haipeng Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
YK-4-279
telomerase reverse transcriptase
thyroid cancer
apoptosis
E-twenty-six transcription factor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.649323/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.649323/full

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