AN EXPERIMENTAL STUDY OF THE EFFECT OF RARE POLYMORPHISMS OF HUMAN HBB, HBD AND F9 PROMOTER TATA BOXES ON THE KINETICS OF INTERACTION WITH THE TATA-BINDING PROTEIN

AN EXPERIMENTAL STUDY OF THE EFFECT OF RARE POLYMORPHISMS OF HUMAN HBB, HBD AND F9 PROMOTER TATA BOXES ON THE KINETICS OF INTERACTION WITH THE TATA-BINDING PROTEIN

Human genes HBB, HBD and F9 belong to the hematopoiesis system. The deficiency or excess of these genes’ products is the cause of hereditary thalassemias of various severity and haemophilia B Leyden. Previously, it was shown that a number of annotated single-nucleotide polymorphisms of TATA boxes of...

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Bibliographic Details
Main Authors: E. B. Sharypova, I. A. Drachkova, E. V. Kashina, D. A. Rasskazov, P. M. Ponomarenko, M. P. Ponomarenko, N. А. Kolchanov, L. K. Savinkova
Format: Article
Language:English
Published: Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2018-03-01
Series:Vavilovskij Žurnal Genetiki i Selekcii
Subjects:
single nucleotide polymorphism
hematopoies genes
rare polymorphisms
orphan diseases
promoter
tata-box
Online Access:https://vavilov.elpub.ru/jour/article/view/1375

Internet

https://vavilov.elpub.ru/jour/article/view/1375

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