Impact of preexisting adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine.

Impact of preexisting adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine.

The prevalence of preexisting immunity to adenoviruses in the majority of the human population might adversely impact the development of adaptive immune responses against adenovirus vector-based vaccines. To address this issue, we primed BALB/c mice either intranasally (i.n.) or intramuscularly (i.m...

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Bibliographic Details
Main Authors: Aseem Pandey, Neetu Singh, Sai V Vemula, Laurent Couëtil, Jacqueline M Katz, Ruben Donis, Suryaprakash Sambhara, Suresh K Mittal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3303828?pdf=render

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http://europepmc.org/articles/PMC3303828?pdf=render

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