Discovery of Potential M2 Channel Inhibitors Based on the Amantadine Scaffold via Virtual Screening and Pharmacophore Modeling

Discovery of Potential M2 Channel Inhibitors Based on the Amantadine Scaffold via Virtual Screening and Pharmacophore Modeling

The M2 channel protein on the influenza A virus membrane has become the main target of the anti-flu drugs amantadine and rimantadine. The structure of the M2 channel proteins of the H3N2 (PDB code 2RLF) and 2009-H1N1 (Genbank accession number GQ385383) viruses may help researchers to solve the drug-...

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Bibliographic Details
Main Authors: Ly Le, Linh Tran, Sy Bing Choi, Belal O. Al-Najjar, Muhammad Yusuf, Habibah A. Wahab
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Molecules
Subjects:
M2 channel inhibitors
adamantane-based drugs
virtual screening
pharmacophore modeling
Online Access:http://www.mdpi.com/1420-3049/16/12/10227/

Internet

http://www.mdpi.com/1420-3049/16/12/10227/

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