Oxidation of low density lipoprotein by thiols: superoxide-dependent and -independent mechanisms.

Oxidation of low density lipoprotein by thiols: superoxide-dependent and -independent mechanisms.

Oxidatively damaged low density lipoprotein (LDL) may cause macrophages to accumulate cholesterol in an unregulated manner, initiating the development of atherosclerotic lesions. Cultured smooth muscle cells oxidize LDL by a superoxide (O2-)-dependent mechanism that requires L-cystine and redox-acti...

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Bibliographic Details
Main Authors: Jay W. Heinecke, Mitsunobu Kawamura, Lucy Suzuki, Alan Chait
Format: Article
Language:English
Published: Elsevier 1993-12-01
Series:Journal of Lipid Research
Subjects:
scavenger receptor
superoxide dismutase
lipid peroxidation
thiyl radical
macrophage
lipoprotein modification
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520353475

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http://www.sciencedirect.com/science/article/pii/S0022227520353475

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