IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model

Abstract Background Inhibition of inositol-requiring enzyme-1 alpha (IRE1α), one of the sensor signaling proteins associated with endoplasmic reticulum (ER) stress, has been shown to alleviate brain injury and improve neurological behavior in a neonatal hypoxic-ischemic encephalopathy (HIE) rat mode...

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Bibliographic Details
Main Authors: Juan Huang, Weitian Lu, Desislava Met Doycheva, Marcin Gamdzyk, Xiao Hu, Rui Liu, John H. Zhang, Jiping Tang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
Hypoxic-ischemic encephalopathy
IRE1α
miR-125
NLPR1
Inflammasome
Pyroptosis
Online Access:http://link.springer.com/article/10.1186/s12974-020-01796-3

Internet

http://link.springer.com/article/10.1186/s12974-020-01796-3

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