Comprehensive analysis of DNA methylation and gene expression in orally tolerized T cells.

T cell anergy is known to be a crucial mechanism for various types of immune tolerance, including oral tolerance. The expression of several anergy-specific genes was reportedly up-regulated in anergic T cells, and played important roles in the cells. However, how the genes were up-regulated has not...

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Bibliographic Details
Main Authors: Ayano Toyoda, Toshinori Kozaki, Kazuo Ishii, Momoka Taniishi, Makoto Hattori, Hiroshi Matsuda, Tadashi Yoshida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229042