Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Abstract Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could functi...

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Bibliographic Details
Main Authors: Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Respiratory Research
Subjects:
Cystic fibrosis
Inflammation
Kalydeco
Ivacaftor
Tezacaftor
Lumacaftor
Online Access:https://doi.org/10.1186/s12931-019-1214-8

Internet

https://doi.org/10.1186/s12931-019-1214-8

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