Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system

Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system

Abstract Background Long-term use of steroid may lead to osteonecrosis of the femoral head (ONFH). Mechanical stress may help bone formation and remodeling. This study aimed to probe the role of mechanical stress in the femoral head recovery in rats. Methods Rat models with ONFH were induced by ster...

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Bibliographic Details
Main Authors: Dapeng Fu, Kairong Qin, Sheng Yang, Jianmin Lu, Haoyi Lian, Dewei Zhao
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Musculoskeletal Disorders
Subjects:
Mechanical stress
Osteonecrosis of femoral head
OPG/RANK/RANKL
Bone density
Osteogenesis
Bone recovery
Online Access:http://link.springer.com/article/10.1186/s12891-020-03301-6

Internet

http://link.springer.com/article/10.1186/s12891-020-03301-6

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