Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma

Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma

Sarcomas are a diverse group of bone and soft tissue tumors that account for over 10% of childhood cancers. Outcomes are particularly poor for children with refractory, relapsed, or metastatic disease. Chimeric antigen receptor T (CAR T) cells are an exciting form of adoptive cell therapy that poten...

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Bibliographic Details
Main Authors: Rachael L. Terry, Deborah Meyran, Emmy D. G. Fleuren, Chelsea Mayoh, Joe Zhu, Natacha Omer, David S. Ziegler, Michelle Haber, Phillip K. Darcy, Joseph A. Trapani, Paul J. Neeson, Paul G. Ekert
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
sarcoma
immunotherapy
CAR T cells
Online Access:https://www.mdpi.com/2072-6694/13/18/4704

Internet

https://www.mdpi.com/2072-6694/13/18/4704

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