Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genes

Improving the production of 22-hydroxy-23,24-bisnorchol-4-ene-3-one from sterols in Mycobacterium neoaurum by increasing cell permeability and modifying multiple genes

Abstract Background The strategy of modifying the sterol catabolism pathway in mycobacteria has been adopted to produce steroidal pharmaceutical intermediates, such as 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), which is used to synthesize various steroids in the industry. However, the producti...

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Bibliographic Details
Main Authors: Liang-Bin Xiong, Hao-Hao Liu, Li-Qin Xu, Wan-Ju Sun, Feng-Qing Wang, Dong-Zhi Wei
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Microbial Cell Factories
Subjects:
Mycobacterium
22-Hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC)
mmpL3
choM
cyp125
fadA5
Online Access:http://link.springer.com/article/10.1186/s12934-017-0705-x

Internet

http://link.springer.com/article/10.1186/s12934-017-0705-x

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