Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids

Abstract Gene therapy is being investigated for a range of serious lung diseases, such as cystic fibrosis and emphysema. Recombinant adeno-associated virus (rAAV) is a well-established, safe, viral vector for gene delivery with multiple naturally occurring and artificial serotypes available displayi...

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Bibliographic Details
Main Authors: Helena Meyer-Berg, Lucia Zhou Yang, María Pilar de Lucas, Alberto Zambrano, Stephen C. Hyde, Deborah R. Gill
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Stem Cell Research & Therapy
Subjects:
human embryonic stem cells
stem cell-based tissue model
gene therapy
rAAV
AAV capsids
AAV serotypes
Online Access:http://link.springer.com/article/10.1186/s13287-020-01950-x

Internet

http://link.springer.com/article/10.1186/s13287-020-01950-x

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