Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

Abstract Background Long regarded as an epicenter of drug-resistant malaria, Southeast Asia continues to provide new challenges to the control of Plasmodium falciparum malaria. Recently, resistance to the artemisinin combination therapy partner drug piperaquine has been observed in multiple location...

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Bibliographic Details
Main Authors: Megan R. Ansbro, Christopher G. Jacob, Roberto Amato, Mihir Kekre, Chanaki Amaratunga, Sokunthea Sreng, Seila Suon, Olivo Miotto, Rick M. Fairhurst, Thomas E. Wellems, Dominic P. Kwiatkowski
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Malaria Journal
Subjects:
Malaria
Piperaquine
Plasmepsin
qPCR
Cambodia
Copy number
Online Access:http://link.springer.com/article/10.1186/s12936-020-03249-x

Internet

http://link.springer.com/article/10.1186/s12936-020-03249-x

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