Removal of the bile acid pool upregulates cholesterol 7α-hydroxylase by deactivating FXR in rabbits

Removal of the bile acid pool upregulates cholesterol 7α-hydroxylase by deactivating FXR in rabbits

We investigated the role of the orphan nuclear receptor farnesoid X receptor (FXR) in the regulation of cholesterol 7α-hydroxylase (CYP7A1), using an in vivo rabbit model, in which the bile acid pool, which includes high affinity ligands for FXR, was eliminated. After 7 days of bile drainage, the en...

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Bibliographic Details
Main Authors: Guorong Xu, Lu-xing Pan, Sandra K. Erickson, Barry M. Forman, Benjamin L. Shneider, M. Ananthanarayanan, Xiaogui Li, Sarah Shefer, N. Balasubramanian, Lin Ma, Hitoshi Asaoka, Steven R. Lear, Lien B. Nguyen, Isabelle Dussault, Frederick J. Suchy, G. Stephen Tint, Gerald Salen
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Journal of Lipid Research
Subjects:
bile salt export pump
biosynthesis
farnesoid X receptor
ileal bile acid-binding protein
orphan nuclear receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520301851

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http://www.sciencedirect.com/science/article/pii/S0022227520301851

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