The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be broadly divided in two classes: single-domain ‘sho...

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Bibliographic Details
Main Authors: Hiraku Takada, Mohammad Roghanian, Victoriia Murina, Ievgen Dzhygyr, Rikinori Murayama, Genki Akanuma, Gemma C. Atkinson, Abel Garcia-Pino, Vasili Hauryliuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
ppGpp
Rel
ACT
RRM
stringent response
ribosome
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00277/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00277/full

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