Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy

Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy

The post-translational conversion of the ubiquitously expressed cellular form of the prion protein, PrPC, into its misfolded and pathogenic isoform, known as prion or PrPSc, plays a key role in prion diseases. These maladies are denoted transmissible spongiform encephalopathies (TSEs) and affect bot...

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Bibliographic Details
Main Authors: Gregor Ilc, Ivana Biljan, Giuseppe Legname, Janez Plavec, Gabriele Giachin
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
prion protein
prions
genetic mutations
polymorphisms
prion diseases
3D structure
NMR spectroscopy
Online Access:http://www.mdpi.com/1420-3049/18/8/9451

Internet

http://www.mdpi.com/1420-3049/18/8/9451

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