Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitotoxicity

Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) where the communication ability of nerve cells in the brain and spinal cord with each other gets impaired. Some current findings suggest the role of glutamate excitotoxicity in the development and progr...

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Bibliographic Details
Main Authors: Ankit A. Gilani, Ranjeet Prasad Dash, Mehul N. Jivrajani, Sandeep Kumar Thakur, Manish Nivsarkar
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Advances in Pharmacological Sciences
Online Access:http://dx.doi.org/10.1155/2014/632376