Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu)

Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu)

Abstract Background Local ischemia and defective osteogenesis are implicated in the progression of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies have revealed that exosomes released from adipose-derived stem cells (ASCs) play important roles in ONFH therapy. Th...

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Bibliographic Details
Main Authors: Kai Nan, Yuankai Zhang, Xin Zhang, Dong Li, Yan Zhao, Zhaopu Jing, Kang Liu, Donglong Shang, Zilong Geng, Lihong Fan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
miR-378
Exosomes
ASCs
ONFH
Sufu
Shh signaling
Online Access:https://doi.org/10.1186/s13287-021-02390-x

Internet

https://doi.org/10.1186/s13287-021-02390-x

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