Ventral Tegmental Area GABA Neurons Are Resistant to GABA(A) Receptor-Mediated Inhibition During Ethanol Withdrawal

Ventral Tegmental Area GABA Neurons Are Resistant to GABA(A) Receptor-Mediated Inhibition During Ethanol Withdrawal

The neural mechanisms underlying alcohol dependence are not well-understood. GABAergic neurons in the ventral tegmental area (VTA) are a relevant target for ethanol. They are inhibited by ethanol at physiologically-relevant levels in vivo and display marked hyperexcitability during withdrawal. In th...

Full description

Bibliographic Details
Main Authors: Ashley C. Nelson, Stephanie B. Williams, Stephanie S. Pistorius, Hyun J. Park, Taylor J. Woodward, Andrew J. Payne, J. Daniel Obray, Samuel I. Shin, Jennifer K. Mabey, Scott C. Steffensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neuroscience
Subjects:
VTA
GABA
neurons
muscimol
GABA(A) receptor
alcohol
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00131/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00131/full

Similar Items