Sequential loss of LC noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration

Sequential loss of LC noradrenergic and dopaminergic neurons results in a correlation of dopaminergic neuronal number to striatal dopamine concentration

Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson’s disease (PD) and the LC exhibits neuropathological changes early in the disease process. It has been suggested that a loss of LC neurons can enhance the susceptibility of dopaminergic neurons to damage. To det...

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Bibliographic Details
Main Authors: Patricia eSzot, Allyn eFranklin, Carl eSikkema, Charles W Wilkinson, Murray A Raskind
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Pharmacology
Subjects:
Catecholamines
Locus Coeruleus
Substantia Nigra
Ventral Tegmental Area
Striatum
6-hydroxydopamine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00184/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00184/full

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