Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.

Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.

OBJECTIVE:Polypyrimidine tract-binding protein 1 (PTBP1) promotes stability and translation of mRNAs coding for insulin secretion granule proteins and thereby plays a role in β-cells function. We studied whether common genetic variations within the PTBP1 locus influence insulin secretion, and/or pro...

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Bibliographic Details
Main Authors: Martin Heni, Caroline Ketterer, Robert Wagner, Katarzyna Linder, Anja Böhm, Silke A Herzberg-Schäfer, Fausto Machicao, Klaus-Peter Knoch, Andreas Fritsche, Harald Staiger, Hans-Ulrich Häring, Michele Solimena
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3471934?pdf=render

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http://europepmc.org/articles/PMC3471934?pdf=render

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