Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury

The clinical trials employing neuroprotectants targeting single, early pathogenic mechanisms in stroke have so far been barely successful. We found in human postmortem stroke brains that in addition to apoptosis, necroptosis also contributed to neuronal damage. Thus, a new strategy targeting both me...

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Bibliographic Details
Main Authors: Fang Han, Xiaoming Guan, Wei Guo, Bai Lu
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300993