Electrical Abnormalities in Dopaminergic Neurons of the Substantia Nigra in Mice With an Aromatic L-Amino Acid Decarboxylase Deficiency

Electrical Abnormalities in Dopaminergic Neurons of the Substantia Nigra in Mice With an Aromatic L-Amino Acid Decarboxylase Deficiency

Aromatic L-acid decarboxylase (AADC) deficiency causes severe motor disturbances in affected children. A putamen-targeted gene therapy improves the motor function of patients. The present study investigated the electrical properties of dopaminergic (DA) neurons in the substantia nigra compacta (SNc)...

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Bibliographic Details
Main Authors: Shih-Yin Ho, Yin-Hsiu Chien, Li-Kai Tsai, Shin-ichi Muramatsu, Wuh-Liang Hwu, Horng-Huei Liou, Ni-Chung Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
aromatic L-acid decarboxylase
motor disturbances
after-hyperpolarization
substantia nigra
gene therapy
dopaminergic neuron
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00009/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00009/full

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