Synthesis of Novel Methyl 7-[(Hetero)arylamino]thieno[2,3-<i>b</i>]pyrazine-6-carboxylates and Antitumor Activity Evaluation: Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Toxicity in Non-Tumor Cells

Synthesis of Novel Methyl 7-[(Hetero)arylamino]thieno[2,3-<i>b</i>]pyrazine-6-carboxylates and Antitumor Activity Evaluation: Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Toxicity in Non-Tumor Cells

Several novel methyl 7-[(hetero)arylamino]thieno[2,3-<i>b</i>]pyrazine-6-carboxylates were synthesized by Pd-catalyzed C–N Buchwald–Hartwig cross-coupling of either methyl 7-aminothieno[3,2-<i>b</i>]pyrazine-6-carboxylate with (hetero)arylhalides or 7-bromothieno[2,3-<i>...

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Bibliographic Details
Main Authors: Juliana M. Rodrigues, Ricardo C. Calhelha, António Nogueira, Isabel C. F. R. Ferreira, Lillian Barros, Maria-João R. P. Queiroz
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
C–N Buchwald–Hartwig coupling
thieno[2,3-<i>b</i>]pyrazines
antitumor activity
gastric adenocarcinoma
cell cycle
apoptosis
Online Access:https://www.mdpi.com/1420-3049/26/16/4823

Internet

https://www.mdpi.com/1420-3049/26/16/4823

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