Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.

Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.

Hematopoietic stem cell (HSC) gene therapy has cured immunodeficiencies including X-linked severe combined immunodeficiency (SCID-X1) and adenine deaminase deficiency (ADA). For these immunodeficiencies corrected cells have a selective advantage in vivo, and low numbers of gene-modified cells are su...

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Bibliographic Details
Main Authors: Grant D Trobridge, Brian C Beard, Robert A Wu, Christina Ironside, Punam Malik, Hans-Peter Kiem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3441638?pdf=render

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http://europepmc.org/articles/PMC3441638?pdf=render

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