The transcription factor nurr1 exerts concentration-dependent effects on target genes mediating distinct biological processes

The transcription factor nurr1 exerts concentration-dependent effects on target genes mediating distinct biological processes

The transcription factor nurr1 plays a pivotal role in the development and maintenance of neurotransmitter phenotype in midbrain dopamine neurons. Conversely, decreased nurr1 expression is associated with a number of dopamine-related CNS disorders, including Parkinson’s disease and drug addiction. I...

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Bibliographic Details
Main Authors: Magen M Johnson, Sharon K Michelhaugh, Mohamad eBouhamdan, Carl J Schmidt, Michael J Bannon
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Neuroscience
Subjects:
human
transcription factor
neurodegeneration
Nurr1
dopamine cell
gene expression profile
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00135/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00135/full

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