Generation of Combinatorial Lentiviral Vectors Expressing Multiple Anti-Hepatitis C Virus shRNAs and Their Validation on a Novel HCV Replicon Double Reporter Cell Line

Generation of Combinatorial Lentiviral Vectors Expressing Multiple Anti-Hepatitis C Virus shRNAs and Their Validation on a Novel HCV Replicon Double Reporter Cell Line

Despite the introduction of directly acting antivirals (DAAs), for the treatment of hepatitis C virus (HCV) infection, their cost, patient compliance, and viral resistance are still important issues to be considered. Here, we describe the generation of a novel JFH1-based HCV subgenomic replicon doub...

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Bibliographic Details
Main Authors: Hossein M. Elbadawy, Mohi I. Mohammed Abdul, Naif Aljuhani, Adriana Vitiello, Francesco Ciccarese, Mohamed A. Shaker, Heba M. Eltahir, Giorgio Palù, Veronica Di Di Antonio, Hanieh Ghassabian, Claudia Del Del Vecchio, Cristiano Salata, Elisa Franchin, Eleonora Ponterio, Saleh Bahashwan, Khaled Thabet, Mekky M. Abouzied, Ahmed M. Shehata, Cristina Parolin, Arianna Calistri, Gualtiero Alvisi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
hepatitis C virus
reporter cell line
antivirals
gene therapy
siRNA
Online Access:https://www.mdpi.com/1999-4915/12/9/1044

Internet

https://www.mdpi.com/1999-4915/12/9/1044

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