FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures

The mitochondrial toxin 3-nitropropionic acid (3-NP) has been largely used to study neurodegenerative disorders in which bioenergetic defects are implicated. In the present study, we analyzed the molecular pathways involved in FK506 neuroprotection against cell death induced by 3-NP, using cultured...

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Bibliographic Details
Main Authors: Sandra Almeida, António Domingues, Luís Rodrigues, Catarina R. Oliveira, A. Cristina Rego
Format: Article
Language:English
Published: Elsevier 2004-12-01
Series:Neurobiology of Disease
Subjects:
FK506
3-Nitropropionic acid
Mitochondria
Bcl-2
Bax
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001512

Internet

http://www.sciencedirect.com/science/article/pii/S0969996104001512

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