Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke

Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke

Background/Aims: Neurotrophic effects and immunosuppression are the main therapeutic mechanisms of mesenchymal stem cells (MSCs) in stroke treatment. Neurotrophins are produced by graft cells, host neurons, astrocytes, and even microglia/macrophages. Meanwhile, MSCs can increase inflammation if they...

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Bibliographic Details
Main Authors: XiaoBo Li, Min Huang, RenChao Zhao, ChunSong Zhao, Yao Liu, HaiQiang Zou, Ling Chen, YunQian Guan, Y. Alex Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cerebral ischemia
Mesenchymal stem cell
Microglia
Macrophages
Transplantation
Online Access:https://www.karger.com/Article/FullText/489384

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https://www.karger.com/Article/FullText/489384

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