Enhanced Solubility and Anticancer Potential of Mansonone G By β-Cyclodextrin-Based Host-Guest Complexation: A Computational and Experimental Study

Enhanced Solubility and Anticancer Potential of Mansonone G By β-Cyclodextrin-Based Host-Guest Complexation: A Computational and Experimental Study

Mansonone G (MG), a plant-derived compound isolated from the heartwood of <i>Mansonia gagei</i>, possesses a potent antitumor effect on several kinds of malignancy. However, its poor solubility limits the use for practical applications. Beta-cyclodextrin (&#946;CD), a cyclic oligosac...

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Bibliographic Details
Main Authors: Panupong Mahalapbutr, Piyanuch Wonganan, Thanapon Charoenwongpaiboon, Manchumas Prousoontorn, Warinthorn Chavasiri, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
beta-cyclodextrins
inclusion complex
mansonone g
molecular dynamics simulation
lung cancer
Online Access:https://www.mdpi.com/2218-273X/9/10/545

Internet

https://www.mdpi.com/2218-273X/9/10/545

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