A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling

A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling

Abstract The cellular consequences of N-Methyl-D-Aspartate receptor (NMDAR) stimulation depend on the receptors’ subcellular localization. Synaptic NMDARs promote plasticity and survival whereas extrasynaptic NMDARs mediate excitotoxicity and contribute to cell death in neurodegenerative diseases. T...

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Bibliographic Details
Main Authors: Carlos Bas-Orth, Mirja Koch, David Lau, Bettina Buchthal, Hilmar Bading
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Brain
Subjects:
MicroRNA
NMDA receptor
Neurotransmitter receptors
Cell death
Neurodegeneration
Kainate
Online Access:https://doi.org/10.1186/s13041-020-0546-0

Internet

https://doi.org/10.1186/s13041-020-0546-0

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