Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

Aims: Chlorogenic acid (CGA) is a phenolic acid that has a wide range of pharmacological effects. However, the protective effects and mechanisms of CGA on liver fibrosis are not clear. This study explored the effects of CGA on miR-21-regulated TGF-β1/Smad7 liver fibrosis in the hepatic stellate LX2...

Full description

Bibliographic Details
Main Authors: Fan Yang, Lei Luo, Zhi-De Zhu, Xuan Zhou, Yao Wang, Juan Xue, Juan Zhang, Xin Cai, Zhi-Lin Chen, Qian Ma, Yun-Fei Chen, Yu-Jie Wang, Ying-Ying Luo, Pan Liu, Lei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
chlorogenic acid
liver fibrosis
TGF-β1
miR-21
Smad7
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00929/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00929/full

Similar Items