Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations

Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing-associated cellular damage and have accelerated woun...

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Bibliographic Details
Main Authors: Elisa Varela, Miguel A. Muñoz-Lorente, Agueda M. Tejera, Sagrario Ortega, Maria A. Blasco
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11739