Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2

Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2

The oncogenic cytoplasmic p21 contributes to cancer aggressiveness and chemotherapeutic failure. However, the molecular mechanisms remain obscure. Here, we show for the first time that cytoplasmic p21 mediates 5-Fluorouracil (5FU) resistance by shuttling p-Chk2 out of the nucleus to protect the tumo...

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Bibliographic Details
Main Authors: Arnatchai Maiuthed, Chuanpit Ninsontia, Katharina Erlenbach-Wuensch, Benardina Ndreshkjana, Julienne K. Muenzner, Aylin Caliskan, Husayn Ahmed P., Chatchai Chaotham, Arndt Hartmann, Adriana Vial Roehe, Vijayalakshmi Mahadevan, Pithi Chanvorachote, Regine Schneider-Stock
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
5-fluorouracil resistance
p21
cytoplasmic p21
Chk2
colorectal cancer
protein interaction
Online Access:http://www.mdpi.com/2072-6694/10/10/373

Internet

http://www.mdpi.com/2072-6694/10/10/373

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