How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress—Therapeutic Implications

How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress—Therapeutic Implications

Tumor cells undergo epithelial-mesenchymal transition (EMT) or macroautophagy (hereafter autophagy) in response to stressors from the microenvironment. EMT ensues when stressors act on tumor cells in the presence of nutrient sufficiency, and mechanistic target of rapamycin (mTOR) appears to be the c...

Full description

Bibliographic Details
Main Authors: Fabrizio Marcucci, Cristiano Rumio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
EMT
autophagy
mTOR
AMPK
stressor
nutrients
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00714/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00714/full

Similar Items