Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity.

Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity.

Central nervous system (CNS) lipid accumulation, inflammation and resistance to adipo-regulatory hormones, such as insulin and leptin, are implicated in the pathogenesis of diet-induced obesity (DIO). Peroxisome proliferator-activated receptors (PPAR α, δ, γ) are nuclear transcription factors that a...

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Bibliographic Details
Main Authors: Heidi E Kocalis, Maxine K Turney, Richard L Printz, Gloria N Laryea, Louis J Muglia, Sean S Davies, Gregg D Stanwood, Owen P McGuinness, Kevin D Niswender
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3423438?pdf=render

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http://europepmc.org/articles/PMC3423438?pdf=render

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